| 主权项 |
1.式I所示的肽-树脂偶联物，<img file="FSB00000523448200011.GIF" wi="750" he="532" />其中R1是不溶性固相，所述固相是聚合的且按照US标准局粒度为100-400目其中A＝Boc-D-Phe-Pro-Arg(R2)-Pro-Gly-Gly-Gly-Gly-Asn(R3)-Gly-Asp(R4)-Phe-Glu(R5)-Glu(R6)-Ile-Pro-Glu(R7)-Glu(R8)-Tyr(R9)-Leu-O-或A＝Fmoc-D-Phe-Pro-Arg(R2)-Pro-Gly-Gly-Gly-Gly-Asn(R3)-Gly-Asp(R4)-Phe-Glu(R5)-Glu(R6)-Ile-Pro-Glu(R7)-Glu(R8)-Tyr(R9)-Leu-O-或A＝NH<sub>2</sub>-D-Phe-Pro-Arg(R2)-Pro-Gly-Gly-Gly-Gly-Asn(R3)-Gly-Asp(R4)-Phe-Glu(R5)-Glu(R6)-Ile-Pro-Glu(R7)-Glu(R8)-Tyr(R9)-Leu-O-，且其中R2是五甲基二氢苯并呋喃基、金刚烷氧基-羰基或异冰片氧基羰基，R9是叔丁基，R3-R8是酸不稳定性保护基。 |
