发明名称 |
CYSTEINE PROTEASE INHIBITORS |
摘要 |
<p>Compounds of the formula I wherein R1a is H; and R1b is C1-C6 alkyl, Carbocyclyl or Het; or R1a and R1b together define a saturated cyclic amine with 3-6 ring atoms; R2a and R2b are H, halo, C1-C4alkyl, C1-C4haloalkyl, C1-C4alkoxy; or R2a and R2b together with the carbon atom to which they are attached form a C3-C6cycloalkyl; R3 is a branched C5-C10alkyl chain, C2-C4haloalkyl or C3-C7cycloalkylmethyl, R4 is Het, Carbocyclyl, optionally substituted as defined in the specification and pharmaceutically acceptable salts, hydrates and N-oxides thereof; are inhibitors of cathepsin S and have utility in the treatment of psoriasis, autoimmune disorders and other disorders such as asthma, arteriosclerosis, COPD and chronic pain.</p> |
申请公布号 |
EP2358692(A1) |
申请公布日期 |
2011.08.24 |
申请号 |
EP20090833050 |
申请日期 |
2009.12.18 |
申请人 |
MEDIVIR UK LTD |
发明人 |
AYESA, SUSANA;BELFRAGE, ANNA, KARIN;CLASSON, BJOERN;GRABOWSKA, URSZULA;HEWITT, ELLEN;IVANOV, VLADIMIR;JOENSSON, DANIEL;KAHNBERG, PIA;LIND, PETER;NILSSON, MAGNUS;ODEN, LOURDES;PELCMAN, MIKAEL;WAEHLING, HORST |
分类号 |
C07C237/22;A61K31/18;A61K31/341;A61K31/343;A61K31/415;A61K31/444;A61K31/4965;A61K31/5375;A61P9/10;A61P11/06;A61P17/06;A61P29/00;A61P37/00;C07C311/21;C07D231/40;C07D237/24;C07D295/195;C07D307/68;C07D307/85 |
主分类号 |
C07C237/22 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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