发明名称 |
A METHOD OF PREPARING A PHARMACEUTICAL CO-CRYSTAL COMPOSITION |
摘要 |
The present invention relates to a method of preparing a pharmaceutical co-crystal composition, said method comprising the steps of: a. simultaneously contacting a supercritical or liquefied gas with solid particles of a pharmaceutically active component and with solid particles of a co-builder to form a co-crystallisation medium containing dissolved pharmaceutically active component and dissolved co-builder as well as solid particles of the pharmaceutically active component and solid particles of the co-builder; b. transforming the solid particles of the pharmaceutically active component and the solid particles of the co-builder into co-crystals of said pharmaceutically active component and said co-builder by keeping the supercritical or liquefied gas in a supercritical or liquid state until at least 80 wt. % of the pharmaceutically active component is incorporated in the crystal matrix of said co-crystals; and c. separating said co-crystals from the supercritical or liquefied gas wherein at least a fraction of the pharmaceutically active component and at least a fraction of the co-builder remain in an undissolved state during the co-crystallisation. The present method enables easy preparation of a pharmaceutical co-crystal composition containing virtually no solvent residue and can suitably be used to prepare co-crystals of highly labile pharmaceutically active components. |
申请公布号 |
EP2170284(B1) |
申请公布日期 |
2011.08.24 |
申请号 |
EP20080779037 |
申请日期 |
2008.07.17 |
申请人 |
FEYECON B.V. |
发明人 |
VAN ROSMALEN, GERDA MARIA;HOFLAND, GERARD WILLEM |
分类号 |
A61K9/14;B01D9/00;B01J3/00 |
主分类号 |
A61K9/14 |
代理机构 |
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