发明名称 |
Dipeptides incorporating selenoamino acids with enhanced bioavailability—synthesis, pharmaceutical and cosmeceutical applications thereof |
摘要 |
Disclosed is a novel synthetic method for isomeric peptides through an appropriate linkage of L-selenomethionine or Se-Methyl-L-selenocysteine with L-glutamic acid. The novel synthetic method produces isomeric peptides of L-selenomethionine or Se-Methyl-L-selenocysteine that exhibit (i) enhanced water solubility; (ii) enhanced rate of dissolution in water; (iii) enhanced bioavailability; (iv) excellent vascular endothelial growth factor promoting activity; (v) excellent anti-5-alpha-reductase activity; (vi) capabilities to prevent/reduce “hair fall” and promote “hair growth”, thereby maintaining a perfect homeostasis for “hair care”. Cosmeceutical and pharmaceutical compositions comprising the isomeric peptides obtained through an appropriate linkage of L-selenomethionine or Se-Methyl-L-selenocysteine with L-glutamic acid are also disclosed. Other dipeptides with several other amino acids and uses thereof are also disclosed.
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申请公布号 |
US8003614(B2) |
申请公布日期 |
2011.08.23 |
申请号 |
US20070749184 |
申请日期 |
2007.05.16 |
申请人 |
SAMI LABS LTD |
发明人 |
MAJEED MUHAMMED;NAGABHUSHANAM KALYANAM;RAMANUJAM RAJENDRAN;CHANDRAMOULI RENUKESHWAR H. |
分类号 |
A61K38/05 |
主分类号 |
A61K38/05 |
代理机构 |
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地址 |
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