发明名称 |
BIFUNCTIONAL MOLECULES WITH ANTIBODY-RECRUITING AND ENTRY INHIBITORY ACTIVITY AGAINST THE HUMAN IMMUNODEFICIENCY VIRUS |
摘要 |
The present invention is directed to new bifunctional compounds and methods for treating HIV infections. The bifunctional small molecules, generally referred to as ARM-H' function through orthogonal pathways, by inhibiting the gp120-CD4 interaction, and by recruiting anti-DNP antibodies to gp120-expressing cells, thereby preventing cell infection and spread of HIV. It has been shown that ARM-H's bind to gp120 and gp-120 expressing cells competitively with CD4, thereby decreasing viral infectivity as shown by an MT-2 cell assay, the binding leading to formation of a ternary complex by recruiting anti-DNP antibodies to bind thereto, the antibodies present in the ternary complex promoting the complement-dependent destruction of the gp120-expressing cells. Compounds and methods are described herein. |
申请公布号 |
WO2011046946(A3) |
申请公布日期 |
2011.08.18 |
申请号 |
WO2010US52344 |
申请日期 |
2010.10.12 |
申请人 |
YALE UNIVERSITY;SPIEGEL, DAVID;PARKER, CHRISTOPHER |
发明人 |
SPIEGEL, DAVID;PARKER, CHRISTOPHER |
分类号 |
C07K19/00;A61K31/4745;A61K39/42;A61P31/18;C07D241/04;C07D487/04 |
主分类号 |
C07K19/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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