METHOD FOR MONITORING PRIMARY DRYING OF A FREEZE-DRYING PROCESS

摘要

A method for monitoring a primary drying phase of a freeze - drying process in a freeze - drying apparatus that includes a drying chamber with one heating surface for supporting a product to be freeze-dried which includes at least one solvent, comprises the following steps: performing a test that is suitable for causing a variation of partial pressure of solvent inside said drying chamber (step 0); at the beginning of said test (t=to) measuring a sublimation flux (jw,o) of the product, a total pressure (Pc,o) and a partial pressure of the solvant (Pw,c,o) in the drying chamber (step1); - estimating, calculating and determining various physical parameters in said drying chamber and of said product.