发明名称 ANGIOTENSIN II RECEPTOR ANTAGONISTS
摘要 A compound having the structure wherein R is an angiotensin receptor antagonist active group, Y is selected from the group consisting of and 2) —C(R1H)OC(O)X((CR12R13)—(CHR10)m—(CH2)n—Zp—(CH2)q—(CHR11)r—(CR16R17))—R5; Z is —O— or —(CR14R15)—; m, n, p, q, and r are independently selected from the group consisting of 0 and 1; X is —O— or —(CR18R19)—; R1 is selected from the group consisting of hydrogen, C1-4 alkyl, aryl and C1-4 alkylaryl; R5 is —O—N═N(O)—NR3R4; or a pharmaceutically acceptable salt or hydrate thereof, which is useful for treating hypertension.
申请公布号 US2011201621(A1) 申请公布日期 2011.08.18
申请号 US201113093550 申请日期 2011.04.25
申请人 MERCK SHARP & DOHME CORP. 发明人 ALI AMJAD;LO MICHAEL MAN-CHU;FRANKLIN CHRISTOPHER;WHITEHEAD BRENT R.
分类号 A61K31/496;A61K31/4178;A61K31/454;A61P7/10;A61P9/12;C07D401/14;C07D403/10;C07D403/14 主分类号 A61K31/496
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