发明名称 PROTEIN KINASE MODULATORS AND METHOD OF USE
摘要 The present invention relates to chemical compounds having a general formula I wherein A, B, D, E, G, H1-5 and R1-4 are defined herein, and synthetic intermediates, which are capable of modulating various protein kinase receptor enzymes and, thereby, influencing various disease states and conditions related to the activities of these kinases. For example, the compounds are capable of modulating kinase enzymes thereby influencing the process of angiogenesis and treating angiogenesis-related diseases and other proliferative disorders, including cancer and inflammation. The invention also includes pharmaceutical compositions, including the compounds, and methods of treating disease states related to the activity of protein kinases.
申请公布号 US2011201602(A1) 申请公布日期 2011.08.18
申请号 US20100952156 申请日期 2010.11.22
申请人 AMGEN INC. 发明人 GEUNS-MEYER STEPHANIE D.;HODOUS BRIAN L.;CHAFFEE STUART C.;TEMPEST PAUL;OLIVIERI PHILLIP R.;JOHNSON REBECCA E.;ALBRECHT BRIAN K.;PATEL VINOD F.;CEE VICTOR J.;KIM JOSEPH L.;BELLON STEVEN;ZHU XIAOTIAN;CHENG YUAN;XI NING;ROMERO KARINA;NGUYEN HANH NHO;DEAK HOLLY L.
分类号 A61K31/541;A61K31/437;A61K31/4427;A61K31/4439;A61K31/444;A61K31/4709;A61K31/496;A61K31/497;A61K31/506;A61K31/517;A61K31/53;A61K31/5377;A61P9/00;A61P11/06;A61P19/02;A61P35/00;C07D213/73;C07D401/04;C07D401/14;C07D405/14;C07D407/14;C07D409/14;C07D413/14;C07D417/14;C07D471/04 主分类号 A61K31/541
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