PREPARATION METHOD OF 4-[(4-CHLOROPHENYL)(2-PYRIDYL)METHOXY]PIPERIDINE

摘要

PURPOSE: A method for preparing 4-[(4-chlorophenyl)(2-pyridyl)methoxy]piperidine is provided to improve reaction speed and to obtained the compound of high yield. CONSTITUTION: A method for preparing 4-[(4-chlorophenyl)(2-pyridyl)methoxy]piperidine comprises: a step of reacting (4-chlorophenyl)(pyridine-2-yl)methanol of chemical formula 2 with trichloroacetonitrile in an organic solvent under the presence of a base catalyst to prepare (4-chlorophenyl)(pyridine-2-yl)methyl 2,2,2-trichloroaceteimidate of chemical formula 3; a step of reacting the compound of chemical formula 3 with tert-butyl-4-hydroxypiperidine-1-carboxylate of chemical formula 4 under the presence of an organic solvent and Lewis acid to prepare a tert-butyl-4-[(4-chlorophenyl)(pyridine-2-yl)methoxy]piperidine-1-carboxylate of chemical formula 5; and a step of deprotecting the compound of chemical formula 5 using acid.