| 摘要 |
<p><P>PROBLEM TO BE SOLVED: To provide a means for vaccinating a human neonatal and a neonatal animal against a foreign antigen and an antigen associated with disease of a human and an animal, respectively. <P>SOLUTION: A virus is used for the production of a medicine for vaccinating or treating a neonatal or prenatal animal, including a human, wherein the virus has capability of infecting a cell of the neonatal or prenatal animal, including a human, but not capable of being replicated to infectious progeny virus in the neonatal or prenatal animal, including a human. The virus is preferably a modified vaccinia virus Ankara. In particular, vaccination of the neonate is carried out against infections with the virus belonging the same virus group as the virus used for vaccination. Moreover, the vaccination of the neonate is carried out against the antigen selected from a foreign antigen and a tumour antigen, which are different from the antigen associated with the virus. By using the virus, a level of a factor activating a dendritic cell or its precursor cell is increased, the number of the dendritic cell or its precursor cell is increased, and (or) a production amount and (or) a cellular content of an interferon (IFN) or IL-12 are increased. <P>COPYRIGHT: (C)2011,JPO&INPIT</p> |
