| 发明名称 |
MONOCLONAL AND CHIMERIC ANTIBODY SPECIFIC FOR HUMAN TUMOR NECROSIS FACTOR |
| 摘要 |
<p><P>PROBLEM TO BE SOLVED: To provide a novel TNF (tumor necrosis factor) antibody overcoming problems of murine antibody immunoexpression and having low immunoexpression and high neutralization activity. <P>SOLUTION: The invention provides: an anti-TNF antibody, fragment and region thereof which are specific for human tumor necrosis factor-α(TNFα) and are useful in vivo for diagnosis and therapy of various TNFα-mediated diseases and symptoms; a polynucleotide encoding a murine and chimeric antibody; methods for producing the antibody; and various approaches of the anti-TNF antibody, fragment, region and derivative thereof for the applications to immunoassays and immunological therapy. <P>COPYRIGHT: (C)2011,JPO&INPIT</p> |
| 申请公布号 |
JP2011155992(A) |
申请公布日期 |
2011.08.18 |
| 申请号 |
JP20110117072 |
申请日期 |
2011.05.25 |
| 申请人 |
NEW YORK UNIV;CENTOCOR INC |
发明人 |
LE JUNMING;VILCEK JAN;DADDONA PETER E;GHRAVEB JOHN;KNIGHT DAVID M;SIEGEL SCOTT A |
| 分类号 |
A61K39/395;C12N15/09;A61K35/00;A61K38/00;A61P1/04;A61P1/16;A61P3/10;A61P5/14;A61P7/00;A61P9/10;A61P17/00;A61P19/02;A61P29/00;A61P31/04;A61P31/10;A61P31/12;A61P35/00;A61P37/00;A61P37/02;C07K1/22;C07K7/06;C07K7/08;C07K14/52;C07K14/525;C07K16/00;C07K16/24;C07K16/46;C07K19/00;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N15/02;C12N15/13;C12P21/02;C12P21/08;C12R1/91;G01N33/53;G01N33/577 |
主分类号 |
A61K39/395 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
|
| 地址 |
|
