SINGLE DOMAIN ANTIBODY AGAINST MUC1

摘要

The present invention relates to a single domain antibody (nanoscale antibody or NanoMAb) containing a mucin antigen 1 (MUC1) complementarity determining region (CDR) and a base sequence thereof, a mouse monoclonal antibody containing some or all of the base sequence or amino acid sequence, a humanized monoclonal antibody, a chimeric monoclonal antibody, a recombinant vector and a transformed host cell, and a pharmaceutical composition for the treatment of cancer or a composition for the diagnosis of cancer, containing some or all of an amino acid sequence constituting the single domain antibody or a polymer thereof. The antibody of the present invention has a specific and high affinity to the MUC1 tumor antigen, with only a variable region of a heavy chain antibody, and may be used for the diagnosis of cancerous tissues and as a therapeutic antitumor target, which binds various functional molecules to antibodies of the present invention to express MUC1.