发明名称 |
ENZYME INHIBITING COMPOUNDS AND METHODS |
摘要 |
The invention provides compounds, compositions, and methods for studying the Rohmer pathway and for treating bacterial infections or parasitic infections. The parasitic infection can be a protozoan infection, such as malaria. The compounds and compositions can also be used as antibiotics, for example, to kill bacteria or parasites, or to inhibit bacterial or parasite growth. The invention further provides inhibitors of isoprenoid biosynthesis enzymes, and methods of inhibiting the activity of isoprenoid biosynthesis enzymes. The compounds can be, for example, alkynes or allenes that bind to a unique Fe of an Fe4S4 cluster of an isoprenoid biosynthesis enzyme. |
申请公布号 |
WO2011044505(A3) |
申请公布日期 |
2011.08.18 |
申请号 |
WO2010US52049 |
申请日期 |
2010.10.08 |
申请人 |
BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS;OLDFIELD, ERIC;WANG, KE;WANG, WEIXUE;ZHANG, YONGHUI |
发明人 |
OLDFIELD, ERIC;WANG, KE;WANG, WEIXUE;ZHANG, YONGHUI |
分类号 |
C07F9/09;A61K31/6615;A61K31/663;A61P31/04;C07F9/40 |
主分类号 |
C07F9/09 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|