SYNTHESIS OF BICYCLIC COMPOUNDS AND METHOD FOR THEIR USE AS THERAPEUTIC AGENTS
摘要
<p>Disclosed embodiments concern the synthesis and use of therapeutic compounds that for treating emerging flu strains and minimizing resistance to such strains. Methods for making the disclosed compounds concern using a base-mediated addition/cyclization sequence followed by functional group manipulation to develop functionalized compounds that can target neuraminidase, which makes them ideal candidates for treating influenza. Pharmaceutical compositions comprising the therapeutic compounds and biologically-acceptable materials are also described. Methods of inhibiting neuraminidase in subjects that are suspected of containing neuraminidase are also described. The use of metabolites of the disclosed compounds can also be used in diagnostic assays for therapeutic dosing of the disclosed compounds.</p>
申请公布号
WO2011097717(A1)
申请公布日期
2011.08.18
申请号
WO2011CA00174
申请日期
2011.02.14
申请人
UNIVERSITY OF VICTORIA INNOVATION AND DEVELOPMENTCORPORATION;WULFF, JEREMY EARLE;BRANT, MICHAEL GLENN;BROMBA, CALEB MATTHEW;BOULANGER, MARTIN JOHN
发明人
WULFF, JEREMY EARLE;BRANT, MICHAEL GLENN;BROMBA, CALEB MATTHEW;BOULANGER, MARTIN JOHN