发明名称 |
ANTIBODIES TO MODIFIED HUMAN IGF-1/E PEPTIDES |
摘要 |
<p>High-specificity antibodies can distinguish between modified (e.g, hIGF-1/Ea 3mut) and endogenous wild-type human IGF-1 proteins. These antibodies have little or no cross-reactivity with hIGF-1 or hIGF-2. They also have little or no cross-reactivity with rodent IGF-1 or IGF-2. The antibodies can be used in pharmacokinetic (PK)/pharamcodynamic (PD) assessments of IGF-1/E peptides that have been administered to humans or animals. A sandwich ELISA assay, using the antibody of the invention as a capture antibody, can quantify the mutant IGF-1/E proteins in samples.</p> |
申请公布号 |
EP2356148(A2) |
申请公布日期 |
2011.08.17 |
申请号 |
EP20090752346 |
申请日期 |
2009.11.10 |
申请人 |
NOVARTIS AG |
发明人 |
XU, JOHN;GAO, YUAN;FORNARO, MARA;HILLENBRAND, RAINER;LEGAY, FRANCOIS;STOELLNER, DANIELA |
分类号 |
C07K16/22 |
主分类号 |
C07K16/22 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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