发明名称 |
SITE-SPECIFIC INHIBITORS OF HISTONE METHYLTRANSFERASE [HMTASE] AND PROCESS OF PREPARATION THEREOF |
摘要 |
The present invention relates to compounds of structural formula I as site-specific inhibitors of histone methyltransferase, where R1 and R1 is —OCH3 or —OH, R2 and R2 is —OH or —OAc; a process of isolating compound of structural formula Ia, where R1 and R1 is —OCH3, R2 and R2 is —OH; a process of preparation of compound of structural formula Ib, where R1 and R1 is —OCH3, R2 and R2 is —OAc; a process of preparation of compound of structural formula Ic, where R1 and R1 is —OH, R2 and R2 is —OH; and use of compounds of structural formula I for manufacture of a medicament for management of cancer and/or disease conditions in a subject in need thereof. |
申请公布号 |
EP2038247(A4) |
申请公布日期 |
2011.08.17 |
申请号 |
EP20070805629 |
申请日期 |
2007.06.26 |
申请人 |
JAWAHARLAL NEHRU CENTRE FOR ADVANCED SCIENTIFIC RESEARCH |
发明人 |
KUNDU, TAPAS, KUMAR;VIKRU, RUTHROTHA, SELVI, BHARATHA;ANNAVARAPU, HARI, KISHORE;KEMPEGOWDA, MANTELINGU |
分类号 |
C07C65/105;A61K31/194;C07C51/42 |
主分类号 |
C07C65/105 |
代理机构 |
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