CYTOSKELETAL ACTIVE RHO KINASE INHIBITOR COMPOUNDS, COMPOSITION AND USE
摘要
The present invention is directed to synthetic cytoskeletal active compounds that are inhibitors of rho-associated protein kinase. The present invention is also directed to pharmaceutical compositions comprising such compounds and a pharmaceutically acceptable carrier. The invention is additionally directed to a method of preventing or treating diseases or conditions associated with cytoskeletal reorganization. In one embodiment of the invention, the method treats increased intraocular pressure, such as primary open-angle glaucoma. The method comprises administering to a subject a therapeutically effective amount of a cytoskeletal active compound of Formula I or Formula II, wherein said amount is effective to influence the actomyosin interactions, for example by leading to cellular relaxation and alterations in cell-substratum adhesions.
申请公布号
EP2099457(A4)
申请公布日期
2011.08.17
申请号
EP20070869450
申请日期
2007.12.18
申请人
INSPIRE PHARMACEUTICALS, INC.
发明人
LAMPE, JOHN W.;WATSON, PAUL S.;SLADE, DAVID J.;PETERSON, WARD M.;CREAN, CHRISTOPHER S.;VITTITOW, JASON L.;DECAMP, JONATHAN BRYAN;PELZ, NICHOLAS F.