发明名称 |
Materials and methods for treatment of cancer and identification of anti-cancer compounds |
摘要 |
The subject invention pertains to the treatment of tumors and cancerous tissues and the prevention of tumorigenesis and malignant transformation through the modulation of JAK/STAT3 intracellular signaling. The subject invention concerns pharmaceutical compositions containing cucurbitacin I, or a pharmaceutically acceptable salt or analog thereof. Another aspect of the invention concerns methods of inhibiting the growth of a tumor by administering a cucurbitacin I, or a pharmaceutically acceptable salt or analog thereof, to a patient, wherein the tumor is characterized by the constitutive activation of the JAK/STAT3 intracellular signaling pathway. The present invention further pertains to methods of moderating the JAK and/or STAT3 signaling pathways in vitro or in vivo using cucurbitacin I, or a pharmaceutically acceptable salt or analog therof. Another aspect of the present invention concerns a method for screening candidate compounds for JAK AND/or STAT3 inhibition and anti-tumor activity.
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申请公布号 |
US7998947(B2) |
申请公布日期 |
2011.08.16 |
申请号 |
US20040472056 |
申请日期 |
2004.03.08 |
申请人 |
UNIVERSITY OF SOUTH FLORIDA |
发明人 |
SEBTI SAID M.;JOVE RICHARD |
分类号 |
A61K31/56;A61K31/58;A61K45/06;A61P35/00;G01N33/50;G01N33/68 |
主分类号 |
A61K31/56 |
代理机构 |
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地址 |
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