PYRIMIDINE DERIVATIVES USED AS PI-3 KINASE INHIBITORS

摘要

PYRIMIDINE DERIVATIVES USED AS PI-3 KINASE INHIBITORS 5 PHOSPHATIDYLINOSITOL (PI) 3-KINASE INHIBITOR COMPOUNDS (1), THEIR PHARMACEUTICALLY ACCEPTABLE SALTS, AND PRODRUGS THEREOF-, COMPOSITIONS OF THE NEW COMPOUNDS, EITHER ALONE OR IN COMBINATION WITH AT LEAST ONE ADDITIONAL THERAPEUTIC AGENT, WITH A PHARMACEUTICALLY ACCEPTABLE CARRIER; AND USES OF THE NEW COMPOUNDS, EITHER ALONE OR IN COMBINATION WITH AT LEAST ONE ADDITIONAL THERAPEUTIC AGENT, IN THE 10 PROPHYLAXIS OR TREATMENT OF PROLIFERATIVE DISEASES CHARACTERIZED BY THE ABNORMAL ACTIVITY OF GROWTH FACTORS, PROTEIN SERINE/THREONINE KINASES, AND PHOSPHOLIPID. KINASES.