发明名称 1-[4-(5-tsüanoindool-3-üül)butüül]-4-(2-karbamoüülbensofuraan-5-üül)piperasiinvesinikkloriidi polümorfsed vormid, nende valmistamismeetodid ja neid sisaldavad farmatseutilised kompositsioonid
摘要 The invention relates to new crystalline modifications of the hydrochloride of 1-[4-(5-cyanoindol-3-yl)butyl]-4-(2-carbamoyl-benzofuran-5-yl)-piperazine, crystalline modification of the dihydrochloride of 1-[4-(5-cyanoindol-3-yl)butyl]-4-(2-carbamoyl-benzofuran-5-yl)-piperazine and amorphous 1-[4-(5-cyanoindol-3-yl)butyl]-4-(2-carbamoyl-benzofuran-5-yl)-piperazine hydrochloride which are suitable in particular for the preparation of solid medicaments for the treatment or prevention of depressive disorders, anxiety disorders, bipolar disorders, mania, dementia, substance-related disorders, sexual dysfunctions, eating disorders, obesity, fibromyalgia, sleeping disorders, psychiatric disorders, cerebral infarct, tension, for the therapy of side-effects in the treatment of hypertension, cerebral disorders, chronic pain, acromegaly, hypogonadism, secondary amenorrhea, premenstrual syndrome and undesired puerperal lactation.
申请公布号 EE05454(B1) 申请公布日期 2011.08.15
申请号 EE20040000019 申请日期 2002.06.05
申请人 MERCK PATENT GMBH 发明人 ANDREAS BATHE;BERND HELFERT;STEFFEN NEUENFELD;HEIKE KNIEL;MATTHIAS BARTELS;SUSANNE RUDOLPH;HENNING BOETTCHER
分类号 A61K31/495;C07D405/00;A61K31/496;A61P1/14;A61P3/04;A61P9/10;A61P9/12;A61P15/00;A61P15/10;A61P21/00;A61P25/04;A61P25/18;A61P25/20;A61P25/22;A61P25/24;A61P25/28;A61P29/02;C07D405/12 主分类号 A61K31/495
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