OPTICALLY ACTIVE 2-HYDROXY TETRAHYDROTHIENOPYRIDINE DERIVATIVES, PREPARATION METHOD AND USE IN MANUFACTURE OF MEDICAMENT THEREOF

摘要

Optically active 2-hydroxy tetrahydrothienopyridine derivatives represented by formula I and pharmaceutically acceptable salts, preparation method and use in the manufacture of a medicament thereof are disclosed. The pharmacodynamic experiment result shows that the present compounds of formula I are useful for inhibiting platelet aggregation; the pharmacokinetic experiment result shows that the present compounds of formula I can convert in vivo into pharmacological metabolites and are therefore useful for inhibiting platelet aggregation. Therefore, the present compounds can be useful for the manufacture of a medicament of preventing or treating thrombosis and embolism relevant diseases.