NOVEL IODOBENZYL-BLEOMYCIN COMPOUND

摘要

Provided is a novel iodobenzyl-bleomycin compound. Also provided are metal complexes that consist of the iodobenzyl-bleomycin compound and various metal atoms, such as an iodobenzyl-Co-bleomycin compound, that can accumulate on malignant tumors, and that have improved biological characteristics in terms of accumulability on malignant tumors compared to conventional compounds. Also provided are methods for synthesizing the iodobenzyl-bleomycin compound and the metal complexes of the iodobenzyl-bleomycin compound and various metal atoms. The novel iodobenzyl-bleomycin compound is synthesized by adding, to a terminal amino group of bleomycin, iodobenzyl iodide synthesized by using iodobenzyl alcohol and iodine as starting materials.