PROCESS FOR THE PREPARATION AND PURIFICATION OF TOPIRAMATE

摘要

A process for the preparation of topiramate in an one pot reaction comprises the following steps: A) reacting 2,3:4, 5 -bis -O- { 1-methylethylidene) -ß-D-f ructopyranose with sulfurylchloride in xylene in the presence of an organic or inorganic base to form 2,3:4, 5-bis-O- (1-methylethylidene) -ß-D-f ructopyranose sulfuryl chloride, B) adding a second organic solvent to the mixture obtained in step A) C) reacting the mixture obtained in step B) with ammonia to form topiramate.