发明名称 |
Methods of Treating Ankylosing Spondylitis Using Anti-TNF Antibodies and Peptides of Human Tumor Necrosis Factor |
摘要 |
Anti-TNF antibodies, fragments and regions thereof which are specific for human tumor necrosis factor-α(TNFα) and are useful in vivo diagnosis and therapy of a number of TNFα-mediated pathologies and conditions, including ankylosing spondylitis, as well as polynucleotides coding for murine and chimeric antibodies, methods of producing the antibody, methods of use of the anti-TNF antibody, or fragment, region or derivative thereof, in immunoassays and immunotherapeutic approaches are provided.
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申请公布号 |
US2011195063(A1) |
申请公布日期 |
2011.08.11 |
申请号 |
US20100885406 |
申请日期 |
2010.09.17 |
申请人 |
CENTOCOR, INC.;NEW YORK UNIVERSITY |
发明人 |
LE JUNMING;VILCEK JAN T.;DADDONA PETER E.;GHRAYEB JOHN;KNIGHT DAVID M.;SIEGEL SCOTT A.;SHEALY DAVID J. |
分类号 |
A61K39/395;C12N15/09;A61K31/7088;A61K35/76;A61K38/00;A61K38/18;A61K38/27;A61K45/00;A61K48/00;A61P1/00;A61P3/10;A61P5/14;A61P9/10;A61P35/00;A61P37/00;A61P43/00;C07K16/24;C07K16/42;C12N5/10;C12N15/13;C12P21/08 |
主分类号 |
A61K39/395 |
代理机构 |
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地址 |
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