发明名称 |
STREPTOCOCCUS PYOGENES CLASSIFICATION |
摘要 |
The difference Lancefield T-serotypes correlate with the sequence of the pilus backbone protein (Pbp) in Streptococcus pyogenes (GAS). We have sequenced Pbp for over 50 GAS strains, representing the major disease-associated serotypes, and have identified 15 Pbp variants. These 15 variants have been shown to determine the specificity of the T-serotyping, such that sequencing of the Pbp from a given GAS strain reliably predicts that strain's T-serotype. thus the invention permits the t-serotype of a GAS strain to be determined based on genotype.
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申请公布号 |
US2011195409(A1) |
申请公布日期 |
2011.08.11 |
申请号 |
US20080741514 |
申请日期 |
2008.11.06 |
申请人 |
NOVARTIS VACCINES AND DIAGNOSTICS SRL |
发明人 |
GRANDI GUIDO;MORA MARIROSA;TELFORD JOHN L.;ZINGARETTI CHIARA;FALUGI FABIANA |
分类号 |
C12Q1/68;C07H21/00;C07K7/06;C07K14/315;C07K16/12;C09K3/00 |
主分类号 |
C12Q1/68 |
代理机构 |
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