| 发明名称 |
PRODRUG OF 9-AMINOMETHYL TETRACYCLINE COMPOUND |
| 摘要 |
PROBLEM TO BE SOLVED: To provide a prodrug of 9-aminomethyl substituted tetracycline compound and a method for using the compound, and to provide a pharmaceutical composition comprising the compound. SOLUTION: There is provided a compound or pharmaceutically acceptable salts thereof expressed by formula (IV), wherein Q" is -(C=O)-E<SP>3</SP>=G<SP>3</SP>; E<SP>3</SP>is oxygen, nitrogen, or a covalent bond; and G<SP>3</SP>is alkyl; heterocyclicalkyl; aryl; alkylcarbonyloxyalkyl; arylcarbonyloxyalkyl; alkyloxycarbonyloxyalkyl; arylalkylcarbonyloxyalkyl; alkyloxyalkylcarbonyloxyalkyl; or alkoxyalkoxycarbonyloxyalkyl. COPYRIGHT: (C)2011,JPO&INPIT
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| 申请公布号 |
JP2011153142(A) |
申请公布日期 |
2011.08.11 |
| 申请号 |
JP20110026689 |
申请日期 |
2011.02.10 |
| 申请人 |
PARATEK PHARMACEUTICALS INC |
发明人 |
KWASI OHEMENG;AMOO VICTOR;KIM OAK;BOWSER TODD;ASSEFA HAREGEWEIN;BHATIA BEENA;BERNIAC JOEL;CHEN JACKSON;GRIER MARK;HONEYMAN LAURA;PAN JINGWEN;MECHICHE RACHID |
| 分类号 |
C07C271/22;A61K31/27;A61P31/04;A61P31/12;A61P33/00;C07C237/26;C07C271/54;C07C275/28;C07C275/30;C07D211/18 |
主分类号 |
C07C271/22 |
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