发明名称 |
SYNTHESIS AND USE OF 2'-SUBSTITUTED-N6-MODIFIED NUCLEOSIDES |
摘要 |
An improved method of preparing a sugar modified nucleoside analog includes a protocol in which a hydroxy group of a sugar is selectively deprotected and oxidized prior to nucleophilic modification of the corresponding carbonyl group. The modified sugar is then coupled to a heterocyclic base that is modified with a dual nucleophilic reagent in a further step that provides N6-modified adenosine analogs with high stereoselectivity.
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申请公布号 |
US2011196144(A1) |
申请公布日期 |
2011.08.11 |
申请号 |
US20100876997 |
申请日期 |
2010.09.07 |
申请人 |
VALEANT PHARMACEUTICALS NORTH AMERICA |
发明人 |
AN HAOYUN;RAMASAMY KANDA;SHAW STEPHANIE |
分类号 |
C07H21/00;C07H19/16;C07H19/167 |
主分类号 |
C07H21/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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