发明名称 |
Hollow Mesoporous Silica Sphere Coated with Gold and Preparation Method Thereof and Use in Cancer Therapy |
摘要 |
The present invention relates to the preparation method of a hollow mesoporous silica sphere coated with gold shell and its use in tumor therapy. In the present invention, the hollow mesoporous silica sphere is made as core and its surface is uniformly coated with the gold shell. The antitumor medicine is loaded in the hollow mesoporous silica sphere and the tumor specific targeting agent is coupled with the surface of the gold shell. The particle size of the hollow mesoporous silica sphere and the thickness of the gold shell are controllable. Based on the Mie Scattering Theory, the hollow mesoporous silica sphere coated with gold shell can adjust its absorption in near-infrared area and convert the light energy of infrared laser into peripheral heat which can kill the malignant tumor cells. The hollow mesoporous silica sphere can be used as a carrier for sustained/controlled release of therapeutic medicine, and the tumor specific targeting agent coupled with the surface of the gold shell can make the medicine have the function of targeting.
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申请公布号 |
US2011196285(A1) |
申请公布日期 |
2011.08.11 |
申请号 |
US200913123337 |
申请日期 |
2009.09.29 |
申请人 |
CHEN DONG;ZHANG YANGDE;TANG FANGQIONG;LIU HUIYU;LI LINLIN;MENG XIANWEI;ZHANG ZONGJIU |
发明人 |
CHEN DONG;ZHANG YANGDE;TANG FANGQIONG;LIU HUIYU;LI LINLIN;MENG XIANWEI;ZHANG ZONGJIU |
分类号 |
A61M37/00;A61K9/16;A61K39/395 |
主分类号 |
A61M37/00 |
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