发明名称 |
Compositions and Methods for Producing Stereoisomerically Pure Statins and Synthetic Intermediates Therefor |
摘要 |
The present disclosure provides ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, method of using the engineered ketoreductase enzymes to synthesize a variety of chirally pure compounds, and the chirally pure compounds prepared therewith.
|
申请公布号 |
US2011195465(A1) |
申请公布日期 |
2011.08.11 |
申请号 |
US20100978022 |
申请日期 |
2010.12.23 |
申请人 |
CODEXIS, INC. |
发明人 |
GIVER LORRAINE JOAN;NEWMAN LISA MARIE;MUNDORFF EMILY;HUISMAN GJALT W.;JENNE STEPHANE J.;ZHU JUN;BEHROUZIAN BEHNAZ;GRATE JOHN H.;LALONDE JAMES |
分类号 |
C12P17/12;C12N9/02;C12P7/62;C12P17/10 |
主分类号 |
C12P17/12 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|