HYDROLYSIS OF MANNOSE-1-PHOSPHO-6-MANNOSE LINKAGE TO PHOSPHO-6-MANNOSE

摘要

Described herein are methods and genetically engineered cells useful for uncapping a mannose- 6 -phosphate residue on an oligosaccharide by using a mannosidase capable of hydrolyzing mannose- 1 -phospho- 6 -mannose linkage to phospho - 6 -mannose.