INHIBITORS OF BIOFILM FORMATION

摘要

Disclosed herein is a composition for inhibiting bacterial biofilm formation comprising carrier and an effective amount of an inhibitor of squalene/phytoene synthesis. Inhibitors may inhibit, for example, HMG-CoA Reductase, squalene synthase, 1-deoxy-D-xylulose 5-phosphate synthase. Examples of such inhibitors are a phosphonosulfonate (e.g., BPH-652, BPH-689, BPH-700), a statin (e.g., mevastatin, lovastatin, atorvastatin, cerivastatin, fluvastatin, pitavastatin, pravastatin, rosuvastatin, and simvastatin), zaragozic acid, clomazone, and lapaquistat acetate or a functional derivative thereof. Also disclosed are substrates comprising the inhibitor of squalene/phytoene synthesis, and methods of inhibiting bacterial biofilm formation.