A composition for delivering an agent to a cell, comprising a bispecific affinity reagent and a pH-responsive, membrane destabilizing polymer. The bispecific affinity reagent may include a first affinity reagent covalently linked to a second affinity reagent, wherein the first affinity reagent binds to a molecule on the surface of a cell, and the second affinity reagent binds to an intracellular target.
申请公布号
EP2352522(A1)
申请公布日期
2011.08.10
申请号
EP20090825146
申请日期
2009.05.13
申请人
UNIVERSITY OF WASHINGTON;PHASERX, INC.
发明人
STAYTON, PATRICK, S.;HOFFMAN, ALLAN, S.;CONVERTINE, ANTHONY;DUVALL, CRAIG, L.;OVERELL, ROBERT;JOHNSON, PAUL
