发明名称 |
Method of measuring an iron-saccharidic complex |
摘要 |
A method for measuring at least one molecular characteristic of an iron-saccharidic complex present in a composition comprising one or more excipients, said complex comprising at least one active hematinic species (AHS), said method comprising: (A) using a first portion of said composition and substantially separating said AHS from said one or more excipients to obtain purified AHS; (B) determining the differential refractive index increment (dn/dc) of said purified AHS, (C) subjecting a second portion of said composition to liquid chromatographic analysis (LCA) having a refractive index (RI) detector and in-line eluate stream detection using laser light scattering (LLS); and (D) calculating said at least one molecular characteristic based on said LCA and said dn/dc value. |
申请公布号 |
EP2275075(A3) |
申请公布日期 |
2011.08.10 |
申请号 |
EP20100011803 |
申请日期 |
2001.10.31 |
申请人 |
CHROMACEUTICAL ADVANCED TECHNOLOGIES, INC. |
发明人 |
BECK, ROBERT A.;MATEER, ROBERT A. |
分类号 |
A61K6/00;G01N30/88;A61K31/295;A61K31/40;A61K31/7016;A61K33/26;A61K45/06;B01J20/281;G01N30/74;G01N30/84;G01N33/00 |
主分类号 |
A61K6/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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