发明名称 |
PREPARING METHOD FOR CONTROLLED RELEASED TYPE TABLET COMPRISING TAMSULOSIN HCL AND THE TABLET PRODUCED THEREOF |
摘要 |
<p>The present invention relates to a simple and effective method for preparing a tamsulosin HCl sustained-release tablet and a tamsulosin HCl sustained-release tablet produced thereby. The method comprises the steps of: dissolving tamsulosin HCl as an active ingredient in an organic solvent; dissolving the tamsulosin HCl solution in hydroxypropylmethylcellulose phthalate to prepare a binder solution; and kneading the binder solution with a hydroxypropylmethylcellulose phthalate/glyceryl dibehenate mixture as an excipient and allows tamsulosin HCl to be released at uniformly controlled amounts in a subtained-release manner in vivo by controlling drug release rate according to different pH environments in vivo, so that it shows improved bioavailability and minimized side effects.</p> |
申请公布号 |
EP1656126(B1) |
申请公布日期 |
2011.08.10 |
申请号 |
EP20040773926 |
申请日期 |
2004.06.15 |
申请人 |
KYUNGDONG PHARM. CO., LTD. |
发明人 |
LEE, BYOUNG-SUK;LEE, AH-RAM;PARK, JONG-SIK;KIM, EUN-JU;GIL, HYUNG-JOON |
分类号 |
A61K31/18;A61K9/20;A61K31/137;A61K47/14 |
主分类号 |
A61K31/18 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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