发明名称 |
A METHOD FOR DETECTING IGF1R/CHR 15 CIRCULATING TUMOR CELLS USING FISH |
摘要 |
The present invention describes methods and probe composition for an automated FISH assay of a blood sample containing circulating tumor cells expressing the IGF-1R gene. The assay provides genetic analysis of suspect circulating tumor cells that have been identified after immunomagnetic selection and fluorescent labeling. Using unique, repeat-free probes to the IGF-1R locus and a chromosome 15 reference probe, cell lines expressing an aberrant number of IGF-1R and Chr 15 signals were detected, including one cell line with a low level of IGF-1R amplification. The ability to directly examine the genetic profile of IGF-1R on circulating tumor cells may provide an automated means for assessing disease and patient response to therapy. |
申请公布号 |
EP2279266(A4) |
申请公布日期 |
2011.08.10 |
申请号 |
EP20090725711 |
申请日期 |
2009.03.25 |
申请人 |
VERIDEX, LLC |
发明人 |
FOULK, BRAD;TERSTAPPEN, LEON, W.M.M. |
分类号 |
C12Q1/68 |
主分类号 |
C12Q1/68 |
代理机构 |
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