Phage display libraries are taught in which the recombinant phage population displays a plurality of potential binding fragments having preferred characteristics of solubility and/or intermolecular interaction. Also taught are methods of biasing display libraries to produce variants which more closely approximate the preferred characteristics of the parental binding fragment.
申请公布号
EP1345967(B1)
申请公布日期
2011.08.10
申请号
EP20010271932
申请日期
2001.12.21
申请人
GRAD, CAROLE, LEGAL REPRESENTATIVE OF KAPLAN, HOWARD;TANHA, JAMSHID;ENTWISTLE, JOCELYN;NARANG, SARAN;DAN, MICHAEL;MACKENZIE, COLIN R.
发明人
TAHNA, JAMSHID;ENTWISTLE, JOCELYN;NARANG, SARAN;DAN, MICHAEL;MACKENZIE, COLIN, R.