CULTIVATED HYBRID CELL STRAIN OF Mus Musculus L ANIMALS - PRODUCER OF MONOCLONAL ANTIBODIES SPECIFIC TO LPS OF CHOLERA VIBRIO 0139 SEROGROUP

摘要

FIELD: medicine. ^ SUBSTANCE: cultivated cell strain of Mus. musculus L animals that is a producer of monoclonal antibodies (MCA) specific to LPS of cholera vibrios 0139 serogroup is produced. Hybridoma is deposited in Specialised Collection of continuous somatic cells of the Vertebrata Institute of Cytology (St.-Petersburg), No. RKKK (P) 674D. The specific activity of the MCA produced by hybridoma under the invention as a diagnostic reagent is proved in a slide agglutination reaction. The produced hybridoma can be applied in creating diagnostic test systems of the monoclonal antibodies for accelerated identification of cholera vibrios O139 serogroup. ^ EFFECT: invention use allows producing the diagnostically significant monoclonal antibodies to LPS epitopes of cholera vibrios 0139 serogroup that allows higher effectiveness of laboratory cholera researches. ^ 3 tbl, 4 ex