发明名称 |
DETECTING ISOMERS USING DIFFERENTIAL DERIVATIZATION MASS SPECTROMETRY |
摘要 |
Methods of evaluating molecular isomers of branched-chain amino acids are featured. The methods can include: derivatizing one or more molecular isomers of branched-chain amino acids in a sample comprising a branched-chain amino acid labeled with one or more heavy atoms as a first standard; adding, to the sample, after derivatization, a nonderivatized or derivatized branched chain amino acid that is labeled with one or more heavy atoms, as a second standard; evaluating the sample using tandem mass spectrometry; and detecting peaks indicative of derivatized and nonderivatized forms of one or more branched-chain amino acids in the sample.
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申请公布号 |
US2011189780(A1) |
申请公布日期 |
2011.08.04 |
申请号 |
US201113084250 |
申请日期 |
2011.04.11 |
申请人 |
PERKINELMER HEALTH SCIENCES, INC. |
发明人 |
CERDA BLAS;CHERKASSKIY ALEX;LI YIJUN |
分类号 |
B01L99/00;G01N33/00;G01N33/48 |
主分类号 |
B01L99/00 |
代理机构 |
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