GPR119 AGONIST

摘要

Disclosed is a compound represented by general formula (I) or (II) or a salt thereof, which is a GPR119 agonist. Also disclosed is a therapeutic agent for diabetes, which contains the compound or a salt thereof as an active ingredient. In the formulae, one of T1-4 represents N and the others represent CR4, or all of T1-4 represent CR4; R2, 3 each represents H, a C1-8 alkyl group; A represents (CH2)1-3, a single bond or the like; B represents (CR5)1-3, a single bond or the like; one of U and V represents N, and the other represents CR7; "-" between W and X represents a single bond or a double bond; W represents C or CR8; X and Y each represents a C1-3 alkylene group (which may be substituted by Hal, OH or the like) or the like; Z represents COOR9, COR10, an alkyloxadiazolyl group, an alkylpyrimidyl group or the like; Q represents N or CH; A0 represents O, a single bond or the like; B0 represents (CR25)1-3, a single bond or the like; one of U0 and V0 represents N, and the other represents CR27; "-" between W0 and X0 represents a single bond or a double bond; W0 represents C or CR28; X0 and Y0 each represents a C1-3 alkylene group (which may be substituted by Hal, OH or the like) or the like; Z0 represents COOR29, COR30, an alkyloxadiazolyl group, an alkylpyrimidyl group or the like; R1, 7, 8, 20, 27, 28 each represents H, Hal, OH, a C1-8 alkyl group or the like; R5, 25 each represents H, a C1-8 alkyl group or a C3-6 cycloalkyl group; R4, 5, 21-23 each represents H, a C1-8 alkylsulfonyl group, a tetrazolyl group, a triazolyl group or the like; and R9, 10, 29, 30 each represents a C1-8 alkyl group or the like.