发明名称 MODULATION OF HIF1(ALPHA) AND HIF2(ALPHA) EXPRESSION
摘要 Compounds, compositions and methods are provided for modulating the expression of HIF1α and/or HIF2α. The compositions comprise oligonucleotides, targeted to nucleic acid encoding HIF1α and HIF2α. Methods of using these compounds for modulation of HIF1α and/or HIF2α expression and for diagnosis and treatment of disease associated with expression of HIF1α and/or HIF2α are provided.
申请公布号 US2011190370(A1) 申请公布日期 2011.08.04
申请号 US20090642534 申请日期 2009.12.18
申请人 ISIS PHARMACEUTICALS, INC. 发明人 WARD DONNA T.;DOBIE KENNETH W.;MARCUSSON ERIC G.;FREIER SUSAN M.
分类号 A61K31/7088;A61K38/00;A61P35/00;C07F9/6558;C07F9/6561;C07H21/04;C12N5/00;C12N15/113 主分类号 A61K31/7088
代理机构 代理人
主权项
地址