发明名称 |
MODULATION OF HIF1(ALPHA) AND HIF2(ALPHA) EXPRESSION |
摘要 |
Compounds, compositions and methods are provided for modulating the expression of HIF1α and/or HIF2α. The compositions comprise oligonucleotides, targeted to nucleic acid encoding HIF1α and HIF2α. Methods of using these compounds for modulation of HIF1α and/or HIF2α expression and for diagnosis and treatment of disease associated with expression of HIF1α and/or HIF2α are provided.
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申请公布号 |
US2011190370(A1) |
申请公布日期 |
2011.08.04 |
申请号 |
US20090642534 |
申请日期 |
2009.12.18 |
申请人 |
ISIS PHARMACEUTICALS, INC. |
发明人 |
WARD DONNA T.;DOBIE KENNETH W.;MARCUSSON ERIC G.;FREIER SUSAN M. |
分类号 |
A61K31/7088;A61K38/00;A61P35/00;C07F9/6558;C07F9/6561;C07H21/04;C12N5/00;C12N15/113 |
主分类号 |
A61K31/7088 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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