PHARMACEUTICAL COMPOSITION FOR TREATMENT OF BONE DISEASES, WHICH CONTAINS PROTEIN COMPRISING BONE MORPHOGENETIC PROTEIN RECEPTOR 1B (BMPR1B) EXTRACELLULAR DOMAIN OR MUTANT THEREOF

摘要

Disclosed is a pharmaceutical composition for the treatment of bone diseases, which contains, as an active ingredient: a protein that comprises a bone morphogenetic protein receptor 1B (BMPR1B) extracellular domain derived from a mammal or a mutant of the BMPR1B extracellular domain, said mutant having 85% or higher sequence identity with the amino acid sequence of the domain and having an effect of increasing the bone mass, bone density and/or bone strength; or a vector comprising a nucleic acid encoding the protein. Examples of the bone diseases may include osteoporosis, osteoarthritis, rheumatoid arthritis, bone diseases associated with malignant tumors or the like, and various bone diseases or disorders associated with the aforementioned diseases.