SAM-6 variants, target and methods of use

摘要

The application relates to variants and functional fragments of the SAM-6 antibody that bind to one or more of glucose regulated protein 78 (Grp78), deglycosylated Grp78, apolipoprotein B100 (apoB100), and glycosylated or deglycosylated lipoproteins VLDL and LDL. Use of the variants and functional fragments in the treatment and diagnosis of neoplasia, tumour, cancer and disorders or diseases associated with excessive levels of LDL or oxidised LDL is also described.