The present invention relates to co-crystals of tramadol and co-crystal formers selected from NSAIDs, processes for preparation of the same and their uses as medicaments or in pharmaceutical formulations, more particularly for the treatment of pain.
In a preferred embodiment, co-crystals of (-)tramadol-(S)-naproxen (1:2) and (+)tramadol-(R)-naproxen (1:2) are prepared.
申请公布号
EP2349238(A1)
申请公布日期
2011.08.03
申请号
EP20090736862
申请日期
2009.10.16
申请人
LABORATORIOS DEL DR. ESTEVE, S.A.
发明人
BUSCHMANN, HELMUT, HEINRICH;SOLÀ CARANDELL, LLUIS;BENET BUCHHOLZ, JORDI;CERÓN BERTRAN, JORDI CARLES;PLATA SALAMAN, CARLOS RAMON;TESSON, NICOLAS
