Modified DNA polymerases have an affinity for DNA such that the polymerase has an ability to incorporate one or more nucleotides into a plurality of separate DNA templates in each reaction cycle. The polymerases are capable of forming an increased number of productive polymerase-DNA complexes in each reaction cycle. The modified polymerases may be used in a number of DNA sequencing applications, especially in the context of clustered arrays.
申请公布号
EP1888743(B1)
申请公布日期
2011.08.03
申请号
EP20060727060
申请日期
2006.05.10
申请人
ILLUMINA CAMBRIDGE LIMITED
发明人
OST, TOBIAS, WILLIAM, BARR;SMITH, GEOFFREY, PAUL;BALASUBRAMANIAN, SHANKAR;RIGATTI, ROBERTO;SANCHES, RAQUEL, MARIA