A fusion protein that is expressed in a recombinant protein body-like assembly (RPBLA) in host eukaryotic cells and organisms is disclosed. More particularly, a biologically active polypeptide fused to a protein sequence that mediates the induction of RPBLA formation is expressed and accumulated in host cells after transformation with an appropriate vector. The eukaryotic host cell does not produce protein bodies in the absence of the fusion protein. Methods for preparing and using the RPBLAs and the fusion protein are also disclosed, as are nucleic acid molecules that encode the fusion proteins.
申请公布号
EP2351834(A2)
申请公布日期
2011.08.03
申请号
EP20110154565
申请日期
2007.02.23
申请人
ERA BIOTECH, S.A.
发明人
HEIFETZ, PETER BERNARD;LLOMPART ROYO, BLANCA;MARZABAL LUNA, PABLO;BASTIDA VIRGILI, MIRIAM;LUDEVID MUGICA, MARIA DOLORES;TORRENT QUETGLAS, MARGARITA;O'CONNOR, KEVIN JAMES;LLOP, MA INMACULADA;PALLISSE BERGWERF, ROSER