AMORPHOUS ROTIGOTINE TRANSDERMAL SYSTEM

摘要

The present invention refers to a transdermal device comprising a backing layer, an adhesive matrix layer comprising a supersaturated concentration of rotigotine substantially in amorphous form within the adhesive matrix, and a release liner. The present invention also refers to a method of preparing an adhesive matrix containing a supersaturated amount of rotigotine substantially in amorphous form. Further, the present invention refers to a method of stabilizing and a method of re-establishing the meta-stable amorphous-drug transdermal system during its manufacturing, storing, shipping and handling process.