发明名称 |
Chimeric and humanized antibodies to alpha5 beta1 integrin that modulate angiogenesis |
摘要 |
The present invention provides chimeric and humanized antibodies that specifically recognize alpha5beta1 integrin, and methods for using the antibodies for reducing or inhibiting angiogenesis in a tissue. Also provided are methods of determining therapeutically acceptable doses of the antibodies and pharmaceutical compositions including the same. |
申请公布号 |
EP2351583(A1) |
申请公布日期 |
2011.08.03 |
申请号 |
EP20100012456 |
申请日期 |
2003.11.26 |
申请人 |
FACET BIOTECH CORPORATION |
发明人 |
RAMAKRISHNAN, VANITHA;POWERS, DAVID;JOHNSON, DALE E.;JEFFREY, URSULA |
分类号 |
A61K39/395;A61P27/00;C07K16/28;C07K16/42;C07K16/46 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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