| 发明名称 |
CRYSTAL FORM OF QUINOLINE COMPOUND AND PROCESS FOR ITS PRODUCTION |
| 摘要 |
<p>A method for producing a drug substance of crystalline pitavastatin calcium excellent in stability, is presented. In the production of a compound (pitavastatin calcium) represented by the formula (1): The water content is adjusted to a level of from 5 to 15%, and the crystal form is controlled to be crystal form A, thereby to obtain a drug substance excellent in stability.</p> |
| 申请公布号 |
EP1697326(B1) |
申请公布日期 |
2011.08.03 |
| 申请号 |
EP20040807807 |
申请日期 |
2004.12.17 |
| 申请人 |
NISSAN CHEMICAL INDUSTRIES, LTD. |
发明人 |
OHARA, YOSHIO;TAKADA, YASUTAKA;MATSUMOTO, HIROO;YOSHIDA, AKIHIRO |
| 分类号 |
C07D215/14;A61K31/47 |
主分类号 |
C07D215/14 |
| 代理机构 |
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