发明名称 Sulfonylpyrrolidine modulators of androgen receptor function and method
摘要 Compounds are provided which are useful in the treatment of androgen receptor-associated conditions, such as age-related diseases, which compounds have the structure wherein R1, R2 and R4, are as defined herein; G is an aryl, heterocyclo or heteroaryl group, wherein said group is mono- or polycyclic, and which is optionally substituted; n is an integer of 1 or 2; m is an integer of 1 or 2; Z is oxygen (—O—) or NR4h; a prodrug ester, all stereoisomers thereof and a pharmaceutically acceptable salt thereof. A method for treating androgen receptor-associated conditions such as age-related diseases is also provided.
申请公布号 US7989640(B2) 申请公布日期 2011.08.02
申请号 US20100880692 申请日期 2010.09.13
申请人 BRISTOL-MYERS SQUIBB COMPANY 发明人 HAMANN LAWRENCE G.;BI YINGZHI;MANFREDI MARK C.;NIRSCHL ALEXANDRA A.;SUTTON JAMES C.
分类号 C07D207/00;A61K31/4015;A61K31/433;C07D207/48;C07D285/06;C07D285/14;C07D498/04 主分类号 C07D207/00
代理机构 代理人
主权项
地址