| 摘要 |
The present invention relates to a nucleic acid construct system comprising (i) first nucleic acid construct comprising a first polynucleotide, said first polynucleotide comprising a first nucleic acid sequence encoding a first expression product, said first nucleic acid sequence being operably linked to a first inducible mammalian transcriptional regulatory sequence; and (ii) second nucleic acid construct comprising a second polynucleotide, said second polynucleotide comprising a second nucleic acid sequence encoding a second expression product, said second nucleic acid sequence being operably linked to a second inducible mammalian transcriptional regulatory sequence, wherein: (a) said first inducible mammalian transcriptional regulatory sequence and said second inducible mammalian transcriptional regulatory sequence are tissue-specific mammalian transcriptional regulatory sequences; or (b) said first inducible mammalian transcriptional regulatory sequence and said second inducible mammalian transcriptional regulatory sequence are tumor-suppressor mammalian transcriptional regulatory sequences.
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